ISOTRETINOIN INDUCED PSYCHOTIC SYMPTOMS

Isotretinoin is an effective treatment for severe and resistant forms of acne. It has proven potential inducing dose-dependent psychiatric side effects, especially in some vulnerable groups patients. Objective: The aim the present article to report a case 22-year-old woman with family history schizophrenia who was diagnosed After unsuccessful antibiotic acne, panic disorder accompanied by depressive symptoms manifested. 20 mg/day used as а second step dermatological period four months, along psychotropic – sertraline 50 flupentixol 1,5 mg/day. When dose increased 40 mg/day, paranoid delusions occurred. manifestation psychotic required discontinuation all medications initiation antipsychotic therapy quetiapine. completely disappeared when quetiapine 300 Conclusion: presented emphasizes need vigilance about symptoms, patients history, current or past medical mental disorder. In such cases, consultation psychiatrist before starting recommended order better clarify benefits risks treatment. endogenous origin psychosis discussed differential diagnostic plan, which requires long-term monitoring state.